New ways to make heterocycles

Heterocycle synthesis is a core feature of our reaction discovery approach. We seek to provide methods to access these hugely important structures that are practically accessible and make use of readily prepared starting materials. Ideally these approaches are modular, and provide structures with useful functionality that can be used to elaborate the core motif as needed for particular targets.

Systems accessed include:

please check back as this page will be updated with new and old examples

Ynamides are readily prepared with different N-substituents. This oxidative cyclisation approach provides a modular entry into a variety of lactam based motifs
Our nucleophilic nitrenoid approach provides a modular and convergent route into oxazoles from readily accessed starting materials – the approach can be applied to nitrogen, oxygen and all-carbon substituted oxazoles as well as the sulfur-examples shown here