We have several projects aimed at developing new chemical scaffolds that can be used to deliver the types of molecules needed to underpin early stage discovery programmes in medical and agrochemical research. We aim to provide high quality molecules – those with desirable physicochemical properties for the end goal, and where the underpinning chemistry enables exploration of the surrounding chemical space.
Our approach is based on developing new chemical transformations to access novel structures that have the characteristics associated with being good hit-like molecules. Our strategies are based on catalysis-based and complexity-building transformations of readily assembled substrates to deliver structures that have high sp3 and 3D character and bear useful functional groups. Our approaches are modular in design so that they can be used to access scaffolds with the structural and functional group variety needed to obtain molecular diversity.
Two projects based on our new transformations are being developed in collaboration with MercaChem BV to build compound libraries. Several other projects are focused on the reaction development and early stage validation as potential scaffolds.
Our new molecular entities are entered into biological screening programmes here in Birmingham and elsewhere and can be made available for other to access.
More information about these projects, the resulting chemical libraries and how to access our libraries for screening will be available in due course. If you are interested in accessing our molecules to screen, or in our chemistry to access compound libraries or particular targets then please get in touch.
A 50 mmol scale gold-catalysed reaction that build a polycyclic ring system that can be derived into different molecular scaffolds for compound library preparation (Elena Claudia)
SynCat Research 